Five Egyptian policemen were killed in a Friday (July 14th) attack on a checkpoint in Giza province, south of Cairo, AFP reported.
The interior ministry said three gunmen opened fire on a police car and then fled, killing a non-commissioned officer, three conscripts and a police employee.
The attack took place near Badrasheen, a town some 20 kilometres from Cairo, where militants have targeted police in the past.
There was no immediate claim of responsibility.
The killings came as police and the army said they are closing in on extremists following a spate of attacks in the Nile Valley and in the Sinai peninsula.
ISIS killed at least 21 soldiers in North Sinai on July 7th, the same day as the militant Hasm group claimed responsibility for shooting dead a secret police officer north of Cairo.
The interior ministry said a day later it had killed 14 alleged ISIS members in a raid on a training camp in the eastern province of Ismailiya.
Earlier this week, the ministry said police had killed six ISIS elements in a shootout in southern Egypt.
While groups like Hasm have mostly targeted policemen and government officials, ISIS also has attacked tourists and Egypt's Coptic Christian minority.